Controlling Coancestry and Thereby Future Inbreeding by Optimum-Contribution Selection Using Alternative Genomic-Relationship Matrices

Controlling inbreeding in dairy cattle using genomic data

Inbreeding depression is the reduction in fitness in offspring resulting from mating individuals that share at least one common ancestor. The objective was to compare the effect of genome-wide and location specific homozygosity on fertility and milk production traits in dairy cattle. Pedigree inbreeding was compared with genomic inbreeding which is the realised proportion of the genome that is ...

Evaluation of inbreeding in laying hens by applying optimum genetic contribution and gene flow theory.

Due to consistent increases of inbreeding of on average 0.95% per generation in layer populations, selection tools should consider both genetic gain and genetic relationships in the long term. The optimum genetic contribution theory using official estimated breeding values for egg production was applied for 3 different lines of a layer breeding program to find the optimal allocations of hens an...

Consequences of applying Optimum Contribution Selection on conventional and genomic based breeding schemes

Locally Epistatic Genomic Relationship Matrices for Genomic Association and Prediction

In plant and animal breeding studies a distinction is made between the genetic value (additive plus epistatic genetic effects) and the breeding value (additive genetic effects) of an individual since it is expected that some of the epistatic genetic effects will be lost due to recombination. In this article, we argue that the breeder can take advantage of the epistatic marker effects in regions...

Unraveling additive from nonadditive effects using genomic relationship matrices.

The application of quantitative genetics in plant and animal breeding has largely focused on additive models, which may also capture dominance and epistatic effects. Partitioning genetic variance into its additive and nonadditive components using pedigree-based models (P-genomic best linear unbiased predictor) (P-BLUP) is difficult with most commonly available family structures. However, the av...